The mutations cause deficiencies in adenine phosphoribosyltransferase (adeF), in hypoxanthine-guanine phosphoribosyltransferase (guaF), in adenine deaminase (adeC), in inosine-guanosine phosphorylase, (guaP), and in GMP reductase (guaC). Keywords:Purine salvage pathway, parasitic protozoa, Trypanosoma, Leishmania, Plasmodium, inhibitors, iminoribitols, nucleoside hydrolase. Similarly, the purine salvage pathway has also been Purine Nucleotide Metabolism Anabolism There are two pathways of synthesis of purine nucleotides : 1.the De Novo synthesis pathway and the 2.Salvage pathway. II. In these cells purine synthesis occurs by salvage pathway. Adenine nucleotide metabolism and synthesis via the purine salvage pathway. Salvage Pathway: The de-novo synthesis does not occur in all the cells. The former is the main synthesis pathway of nucleotides , the latter is important one in brain and bone marrow. As a result, GPAT (the regulated step in purine synthesis) has excess substrate and decreased inhibitors available, and de novo purine synthesis is increased. Brain cells and leukocytes lack this mechanism. SALVAGE PATHWAYS (the reutilization of bases from dietary or catabolic sources) 1. salvage pathway causes increased PRPP levels and decreased IMP and GMP levels. Salvage pathway (recycle pathway): used to recover bases and nucleosides formed during the degradation of RNA and DNA I. De-novo synthesis (synthesis from scratch): it is a biochemical pathway in which nucleotides are synthesized new from simple precursor molecules. Salvage pathway involves synthesis of purine nucleotides from free purine bases, which are salvaged from dietary sources and tissue breakdown. We have isolated numerous mutants containing mutations in the salvage pathways of purine synthesis. Purines are essential molecules for all forms of life. In addition to constituting a backbone of DNA and RNA, purines play roles in many metabolic pathways, such as energy utilization, regulation of enzyme activity, and cell signaling. (1) de-novo synthesis and (2) synthesis by salvage pathways. DE NOVO BIOSYNTHETIC PATHWAYS (building the bases from simple building blocks) The biosynthesis of purine (A and G) begins with the synthesis of the ribose-phosphate Ribose phosphate pyrophospho-KINASE Pentose phosphate The supply of purines is provided by two pathways: the salvage pathway and de novo synthesis. The net formation of purine nucleotides is performed by the de novo pathway, but rapid turnover of nucleic acids, especially RNA, is required for nucleotide production by the salvage pathways. Abstract: For many years, the purine salvage pathway of parasitic protozoa has been regarded as an attractive chemotherapeutic target. 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